BE/BTech & ME/MTech Final Year Projects for Computer Science | Information Technology | ECE Engineer | IEEE Projects Topics, PHD Projects Reports, Ideas and Download | Sai Info Solution | Nashik |Pune |Mumbai
director@saiinfo settings_phone02536644344 settings_phone+919270574718 +919096813348 settings_phone+917447889268
logo


SAI INFO SOLUTION


Diploma | BE |B.Tech |ME | M.Tech |PHD

Project Development and Training

Search Project by Domainwise


Dynamic in vivo X-ray Fluorescence Imaging of Gold in Living Mice Exposed to Gold Nanoparticles


3D Reconstruction in Canonical
Abstract


Dynamic in vivo biodistribution of gold nanoparticles (GNPs) in living mice was first successfully acquired by a pinhole X-ray fluorescence (XRF) imaging system using polychromatic Xrays. The system consisted of fan-beam X-rays to stimulate GNPs and a 2D cadmium zinc telluride (CZT) gamma camera to collect K-shell XRF photons emitted from the GNPs. 2D XRF images of kidney slices of three Balb/C mice were obtained within 2 minutes of irradiation per slice. 40 mg of GNPs suspended in a 0.2 mL phosphate-buffered saline was injected into the mice via a tail vein. The mice were scanned over a 60 min period after the injection of GNPs in order to acquire a dynamic biodistribution of GNPs. The concentrations of GNPs measured by the CZT gamma camera were then validated by inductively coupled plasma atomic emission spectroscopy and ex vivo L-shell XRF measurements using a silicon drift detector. The GNP concentrations in the rightside kidneys were 1.58% by weight (wt%) at T=0 min and 0.77 wt% at T=60 min after the injection. This investigation showed a dramatically reduced scan time and imaging dose. Hence, we conclude that dynamic in vivo XRF imaging of GNPs is technically feasible in a benchtop system. The developed pinhole XRF imaging system can be a potential molecular imaging modality for metal nanoparticles to emerge as a radiosensitizer and a drug-delivery agent

KeyWords
Xray Fluorescence, Pinhole, Gold nanoparticles, in vivo, Molecular imaging



Share
Share via WhatsApp
BE/BTech & ME/MTech Final Year Projects for Computer Science | Information Technology | ECE Engineer | IEEE Projects Topics, PHD Projects Reports, Ideas and Download | Sai Info Solution | Nashik |Pune |Mumbai
Call us : 09096813348 / 02536644344
Mail ID : developer.saiinfo@gmail.com
Skype ID : saiinfosolutionnashik